用高效液相色谱—电化学检测法测定尿中儿茶酚胺(CAs)需对尿样进行预处理。预处理方法很多,其中有氧化铝吸附法,各种有机溶剂提取法、双柱双泵直接进样法和离子交换法等。我们采用一种弱阳离子交换树脂对尿样进行预处理。实验证明,与其它预处理法比较本法操作简便快速。回收率高,对CAs提取的专一性强,适用于临床和实验室的分析和研究。 Urinary Catecholamines (CAs) were pretreated with high performance liquid chromatography-electrochemical detection of urine samples. Pretreatment methods are many, including alumina adsorption, a variety of organic solvent extraction, double-column double-pump direct injection and ion exchange method. We use a weak cation exchange resin for pretreatment of urine samples. Experiments show that compared with other pretreatment method of this method is simple and quick. High recovery rate, high specificity for CAs extraction, suitable for clinical and laboratory analysis and research.