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目的:观察珍葛胶囊对自发性高血压大鼠(Spontaneously hypertensive rats,SHR)血压的影响,并探讨其可能的作用机制。方法:将SHR大鼠随机分为4组,即模型组、珍葛胶囊组、维生素c组、卡托普利组,分别给予生理盐水、珍葛胶囊750mg/kg、维生素c片50mg/kg、卡托普利12.5mg/kg灌胃,每日一次,连续给药两周,并用Wistar-Kyoto(WKY)大鼠作为正常对照组(WKY组),每组15只,分别于给药前后测定血压。给药两周后,分别测定各组大鼠血浆丙二醛、血浆纤维蛋白原、氧化低密度脂蛋白含量,并进行血液流变学指标测定。结果:与WKY组大鼠相比,SHR大鼠给药前后血压均明显偏高(P<0.05);与模型组相比,给药两周后,珍葛胶囊组、卡托普利组大鼠血压明显降低(P<0.05),珍葛胶囊可以显著提高SHR大鼠总体抗氧化能力、降低血浆丙二醛及氧化低密度脂蛋白含量,对SHR大鼠纤维蛋白原含量及血液流变学指标无明显影响。结论:珍葛胶囊可以降低自发性高血压大鼠的血压,其作用机制可能与提高机体抗氧化能力有关,但对血液流变学作用不明显。
Objective: To observe the effect of Zhen Ge capsule on blood pressure in spontaneously hypertensive rats (SHR) and to explore its possible mechanism. Methods: SHR rats were randomly divided into 4 groups: model group, Zhen Ge capsule group, vitamin C group and captopril group. The rats were given normal saline, Zhen Ge capsule 750mg / kg, vitamin C tablets 50mg / kg, Captopril 12.5mg / kg orally, once daily for two weeks, and Wistar-Kyoto (WKY) rats as normal control group (WKY group), 15 rats in each group, before and after administration blood pressure. Two weeks after the administration, the content of plasma malondialdehyde, plasma fibrinogen and oxidized low density lipoprotein in each group were determined, and the hemorrheological indexes were determined. Results: Compared with WKY group, the blood pressure was significantly higher in SHR rats before and after administration (P <0.05). Compared with the model group, Rat blood pressure was significantly lower (P <0.05), Zhen Ge capsule can significantly improve SHR rats overall antioxidant capacity, reduce plasma MDA and oxidized low-density lipoprotein content, SHR rat fibrinogen content and hemorheology Indicators no significant effect. Conclusion: Zhen Ge capsules can reduce the blood pressure in spontaneously hypertensive rats. The mechanism may be related to improving the antioxidant capacity of the body, but its effect on hemorheology is not obvious.