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为了试图重建12例人免疫缺陷病毒Ⅰ-1(HIV-1)感染患者的免疫功能,将他们的未感染HIV-1的同卵孪生同胞的淋巴细胞置于含5％胎牛血清(FCS)、抗-CD3抗体和白介素-2(100IU/ml)的培养液中培养10天后输给相应患者。每次输注的间隔时间为6～8周,经多次输注后,一半的患者在输注后4～12小时内发生阿图斯样反应,表现为体温高于39℃、低血压、寒战、关节痛、肌痛、头疼和/或其它不适症状。用双向免疫扩散法测定输注前、后患者血清标本检测FCS抗体。输注前患者血清标本以上检查均为阴性,两次或两次以上输注经
In an effort to reconstitute immune function in 12 HIV-1 infected patients, their uninfected twin sibling lymphocytes from HIV-1 were plated in 5% fetal calf serum (FCS) , Anti-CD3 antibody and interleukin-2 (100 IU / ml) for 10 days and then administered to corresponding patients. Each infusion interval of 6 to 8 weeks after multiple infusions, half of patients within 4 to 12 hours after infusion of Atos-like reaction occurs, the performance of the body temperature above 39 ℃, hypotension, Chills, joint pain, myalgia, headache, and / or other symptoms. Serum samples from patients before and after infusion were assayed for FCS antibody by two-dimensional immunodiffusion. Patients before transfusion serum samples were negative, twice or more than the infusion