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目的探讨初诊2型糖尿病(T2DM)患者空腹血清抵抗素水平与肥胖和胰岛素抵抗(IR)的关系。方法选取48例肥胖的初诊T2DM患者、48例非肥胖的初诊T2DM患者和52名正常对照者(NC组)。测定受试者空腹血清抵抗素、血糖、血脂及胰岛素水平,测量身高、体重、血压,计算BMI、胰岛素抵抗指数(HOMA-IR)。结果 (1)与NC组相比,T2DM患者血清抵抗素水平明显升高(P<0.01);与非肥胖的T2DM患者相比,肥胖的T2DM患者血清抵抗素水平明显升高(P<0.01)。(2)血清抵抗素水平与HOMA IR、BMI、TG密切相关(P<0.01)。结论 T2DM患者血清抵抗素水平升高,且与肥胖及IR程度相关,因而抵抗素可能在T2DM的发生发展中起重要作用。
Objective To investigate the relationship between fasting serum resistin levels and obesity and insulin resistance (IR) in newly diagnosed type 2 diabetic patients (T2DM). Methods Forty-eight obese newly diagnosed T2DM patients, 48 non-obese newly diagnosed T2DM patients and 52 normal controls (NC group) were enrolled. Fasting serum resistin, blood glucose, blood lipid and insulin levels were measured. Height, weight and blood pressure were measured. BMI and insulin resistance index (HOMA-IR) were calculated. Results Compared with NC group, serum resistin level in T2DM patients was significantly increased (P <0.01). Compared with non-obese T2DM patients, the levels of serum resistin in obese T2DM patients were significantly increased (P <0.01) . (2) Serum resistin level was closely related to HOMA IR, BMI and TG (P <0.01). Conclusion Serum resistin level is elevated in patients with T2DM and is related to the degree of obesity and IR. Therefore, resistin may play an important role in the occurrence and development of T2DM.