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为探讨丘脑底核中谷氨酸能神经元在帕金森病时的变化 ,本研究应用免疫组织化学和形态计量学技术对用 6-OHDA脑内注射制备的偏侧帕金森病大鼠模型丘脑底核谷氨酸能神经元的变化进行了观察和计数。结果发现 ,6-OHDA损毁侧丘脑底核中谷氨酸免疫反应阳性神经元的数量显著高于非损毁侧 (P<0 .0 1)。本研究结果提示 ,帕金森病时黑质多巴胺能神经元的减少可能导致丘脑底核过度兴奋 ,这很可能是产生帕金森病症状及其病情渐进发展的原因之一。
To investigate the changes of glutamatergic neurons in the subthalamic nucleus during Parkinson’s disease, this study used immunohistochemistry and morphometry techniques to study the effects of 6-OHDA intracerebral injection on the hypothalamus Changes in nuclear glutamatergic neurons were observed and counted. The results showed that the number of glutamate-immunoreactive neurons in the basolateral nucleus of the damaged 6-OHDA group was significantly higher than that in the non-lesion side (P <0.01). Our results suggest that a decrease in substantia nigra dopaminergic neurons during Parkinson’s disease may lead to over-excitation of the subthalamic nucleus, which is likely one of the reasons for the development of Parkinson’s disease and its progressive progression.