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本文报道对氨基水杨酸钠(PAS-Na)对亚急性锰中毒大鼠不同脑区,肝和血清中锰,铜含量的影响,大鼠每日ip二氯化锰15 mg·kg~(-1),连续60或84 d;接着,每日ip PAS-Na 80或120 mg·kg~(-1),连续16或21 d,结果表明,锰中毒大鼠体重增加明显减少,脑和肝中锰,铜含量明显增加,以纹状体的锰,铜含量增加最多,锰中毒后PAS—Na治疗可以使脑,肝的锰含量减少,尤以d 78时所观察到的效果更为明显,提示PAS—Na有促排锰作用。
This article reports the effects of sodium aminosalicylate (PAS-Na) on the contents of manganese and copper in different brain regions, liver and serum in rats with sub-acute manganese poisoning. Rats were treated daily with 15 mg · kg ~ -1) for 60 or 84 days. The daily ip PAS-Na 80 or 120 mg · kg -1, for 16 or 21 days, showed that the weight gain of manganese poisoning rats was significantly reduced, The content of manganese and copper in liver increased obviously, and the content of manganese and copper in striatum increased most. After treatment with PAS-Na, the manganese content in brain and liver decreased, especially in d 78 Obviously, suggesting that PAS-Na role in promoting manganese.