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目的探讨香丹注射液对慢性心力衰竭患者心功能及心率变异性的影响。方法慢性心力衰竭患者共80例,随机分为观察组和对照组,各40例。对照组给予常规西医抗心力衰竭治疗。观察组在常规治疗基础上给予香丹注射液。观察两组治疗前和治疗后心功能及心率变异性改变情况。结果观察组治疗后左心室射血分数、每搏输出量、每分输出量与对照组治疗后比较,差异有统计学意义(P<0.05);观察组治疗后24 h窦性心律R-R间期标准差(SDNN)、24 h内每5 min正常RR间期平均值标准差(SDANN)、24 h内相邻RR间期差值的均方根(r MSSD)、相邻RR间期差值>50 ms的心搏数占所有心搏数的百分比(PNN50)与对照组治疗后比较,差异有统计学意义(P<0.05)。结论香丹注射液能够显著改善慢性心力衰竭患者心功能,改善此类患者的心率变异性,改善患者预后。
Objective To investigate the effect of Xiangdan injection on heart function and heart rate variability in patients with chronic heart failure. Methods A total of 80 patients with chronic heart failure were randomly divided into observation group and control group, 40 cases in each. The control group was given conventional Western medicine to treat heart failure. The observation group was given Xiangdan injection on the basis of routine treatment. The changes of heart function and heart rate variability in both groups before and after treatment were observed. Results The left ventricular ejection fraction, stroke volume and output per minute after treatment in the observation group were significantly different from those in the control group after treatment (P <0.05). In the observation group, the sinus rhythm RR interval Standard deviation (SDNN), mean standard deviation (SDANN) of normal RR interval every 5 min in 24 h, root mean square (r MSSD) of difference of adjacent RR interval in 24 h, difference of adjacent RR interval The percentage of heart beats> 50 ms in all beats (PNN50) was significantly different from the control group after treatment (P <0.05). Conclusion Xiangdan injection can significantly improve cardiac function in patients with chronic heart failure, improve heart rate variability in such patients and improve prognosis.