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目的:对某院急诊注射用质子泵抑制剂(PPIs)的使用情况进行分析,为临床合理用药提供参考。方法:采用回顾性调查研究的方法,检索某院HIS,获取2015年7月份使用过注射用PPIs的急诊患者处方,依据SAHP(美国医院药师协会)指南及药品说明书对其临床应用进行合理性分析。结果:在1 754份处方中,统计结果显示某院急诊使用PPIs注射剂的临床诊断不符合使用指征占比24.7%,用法用量不合理的处方占比7.5%,联合用药不合理占比为1.7%,老年患者使用潘妥洛克日剂量超40 mg一项为5.4%,具有统计学意义,其合理性有待进一步讨论研究。结论:某院急诊科使用注射用质子泵抑制剂存在不合理现象。为减轻患者经济负担及降低用药风险,临床医生应规范诊疗行为,做到诊断与用药相适应,杜绝无正当理由超适应证用药;可通过处方点评或信息系统引导用药等干预措施来改善目前的用药现状。
Objective: To analyze the use of proton pump inhibitors (PPIs) for emergency injection in a hospital for providing reference for clinical rational drug use. Methods: A retrospective study was conducted to find out the HIS in a hospital and to obtain the prescription of emergency patients who used PPIs for injection in July 2015. According to the SAHP guidelines and the pharmacopeia, the rationality of clinical application was analyzed . Results: Among 1 754 prescriptions, the statistical results showed that the clinical diagnosis of using PPIs injection in a hospital emergency did not meet the requirements of using 24.7%, the usage of unreasonable dosage accounted for 7.5% and the unreasonable proportion of medication was 1.7 %, The elderly patients using the top dose of Pantoprocer over 40 mg a 5.4%, with statistical significance, its rationality to be further discussed. Conclusion: It is unreasonable to use proton pump inhibitor for emergency department in a hospital. In order to reduce the economic burden of patients and reduce the risk of medication, clinicians should standardize the diagnosis and treatment behavior, so that diagnosis and medication to adapt to eliminate unhealthy reasons for the use of drugs; can be prescription feedback or information systems to guide the use of drugs and other interventions to improve the current Medication status.