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目的 :探讨卡托谱利、灯盏花对充血性心衰患者心率变异性的影响。方法 :对卡托谱利组、灯盏花组、对照组三组充血性心衰患者治疗前后 ,分别采用 2 4h动态心电图分析系统及彩色多谱勒超声心电动图观察分析心率变异性的时域、频域及心功能变化情况。结果 :卡托谱利组显示 :心率变异性的时域指标 :PNN5 0、rMSSD明显增加 (P <0 .0 1) ;心率变异性的频域指标 :有不同程度增加 ,但只有白天HF增加具有统计学意义 (P <0 .0 5 ) ;左室射血分数 :从 (30 .6 2± 10 .2 0 ) %增至 (40 .2 0± 8.72 ) %。灯盏花组显示 :仅有心率变异性的频域指标有不同程度增加 (P <0 .0 5 ) ;左室射血分数 :从 (35 .73± 10 .2 8) %增至 (45 .76± 9.4 7) %。对照组显示 :心率变异性的频域、时域指标及左室射血分数增加均不明显 (P >0 .0 5 )。结论 :卡托谱利、灯盏花治疗充血性心衰患者均可减慢心率和使心率变异性的部分指标修复 ,提示部分改善了充血性心衰患者心脏自主神经的功能状态。
Objective: To investigate the influence of Catolphe and Erigeron on heart rate variability in patients with congestive heart failure. Methods: Before and after the treatment of patients with congestive heart failure, three groups of patients in the Catolipril group, the Erigeron breviscapus group and the control group were respectively analyzed by 24 h dynamic electrocardiogram analysis system and color Doppler echocardiography in the time domain of heart rate variability , Frequency domain and cardiac function changes. Results: The Cato-bolivian group showed that the time domain index of heart rate variability was significantly higher than that of PNN5 0 and rMSSD (P <0.01); the frequency domain index of heart rate variability was increased to some extent, but only increased during daytime (P <0.05). The left ventricular ejection fraction increased from (30.6 ± 10.2)% to (40.0 ± 8.72)%. The Erigeron group showed that only the frequency domain indexes of heart rate variability increased to some extent (P <0.05); the left ventricular ejection fraction increased from (35.73 ± 10.28)% to (45.0%). 76 ± 9.4 7)%. The control group showed that the frequency domain, time domain index and left ventricular ejection fraction increase of heart rate variability were not significant (P> 0.05). CONCLUSION: Both Catolipril and Erigeron in the treatment of congestive heart failure may slow down the heart rate and repair some indicators of heart rate variability, suggesting that the functional status of cardiac autonomic nervous system in patients with congestive heart failure is partially improved.