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目的研究血浆氨基末端前体脑钠肽(NT-proBNP)与心功能的关系。方法采用固相免疫层析法检测152例不同分期慢性肾脏病(CKD)组患者与20例对照组血浆NT-proBNP水平,分析其与心脏彩超各指标、生化指标的关系。结果伴有心衰的各期CKD患者NT-proBNP水平远高于同一分期无心衰患者;非心衰组CKD患者的NT-proBNP水平随着肾小球滤过率的下降逐渐升高;NT-proBNP水平与左房内径以及左室舒张末内径、左室收缩末内径均呈正相关,与心脏射血分数呈负相关。结论 NT-proBNP是早期诊断CKD患者无症状性心功能不全的敏感指标。
Objective To study the relationship between plasma N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac function. Methods The plasma levels of NT-proBNP in 152 patients with chronic kidney disease (CKD) and 20 controls were measured by solid phase immunochromatography. The relationship between them and the indexes of cardiac ultrasound and biochemical indexes were analyzed. Results The levels of NT-proBNP in all CKD patients with heart failure were significantly higher than those without heart failure in the same stage. NT-proBNP levels in CKD patients with non-heart failure group increased gradually with the decrease of glomerular filtration rate -proBNP levels were positively correlated with left atrial diameter and left ventricular end-diastolic diameter, left ventricular end-systolic diameter, and negatively correlated with cardiac ejection fraction. Conclusion NT-proBNP is a sensitive indicator of early diagnosis of asymptomatic cardiac insufficiency in CKD patients.