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目的通过对2型糖尿病合并尿路感染(T2DMUTI)患者与无糖尿病的尿路感染(UTI)患者临床特点与病原菌耐药性分析,为临床合理用药提供科学依据。方法将1 078例T2DMUTI患者作为观察组,UTI患者1 156例作为对照组,回顾性分析2组患者临床资料与病原菌耐药性。结果观察组中女性患者(89.15%)高于男性(10.85%),无症状菌尿发生率、>2次UTI比率、肾盂肾炎发生率明显高于对照组,差异均有统计学意义(P<0.05)。观察组与对照组患者感染均以大肠埃希菌为主。观察组真菌及混合感染高于对照组、差异均有统计学意义(P<0.05)。观察组患者大肠埃希菌对环丙沙星、阿米卡星、头孢他啶、左氧氟沙星、哌拉西林-他唑巴坦、复方新诺明耐药性高于对照组,差异均有统计学意义(P<0.05)。结论临床诊治应早期对T2DMUTI患者进行细菌培养及药敏试验,根据药敏试验结果合理用药。
Objective To provide a scientific basis for clinical rational drug use in patients with type 2 diabetes mellitus (T2DMUTI) and non-diabetic urinary tract infection (UTI). Methods A total of 1 078 T2DMUTI patients were included as observation group and 1 156 UTI patients as control group. The clinical data and pathogenic bacteria resistance of the two groups were retrospectively analyzed. Results The incidence of asymptomatic bacteriuria,> 2 UTI rate and pyelonephritis in observation group were higher than that in male (89.15%), and the difference was statistically significant (P < 0.05). The patients in the observation group and the control group were mainly Escherichia coli. The observation group fungal and mixed infection was higher than the control group, the difference was statistically significant (P <0.05). The resistance of Escherichia coli to ciprofloxacin, amikacin, ceftazidime, levofloxacin, piperacillin-tazobactam and cotrimoxazole in the observation group was higher than that in the control group (P < P <0.05). Conclusion The clinical diagnosis and treatment of T2DMUTI patients should be carried out in early bacterial culture and drug susceptibility testing, drug susceptibility test results based on rational use of drugs.