本文动态观测了被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）发病各期的Ｔｈ１类细胞因子（ＩＬ２，ＩＦＮγ）和Ｔｈ２类细胞因子（ＩＬ４）的变化。结果表明在注射兔抗肾近曲小管刷状缘抗体（ＴｕｂＡｂ）７ｄ后即开始出现蛋白尿，同时ＩＬ２，ＩＦＮγ较正常对照诱生水平降低（Ｐ＜００５），而ＩＬ４诱生水平开始升高；在注射ＴｕｂＡｂ第１４天时，出现大量蛋白尿，此时ＩＬ４进一步升高，与正常对照及注射第７天时ＩＬ４水平均存在统计学差异，ＩＬ４与蛋白尿定量之间并有一定相关性；第２８天时蛋白尿开始降低，ＩＬ２，ＩＦＮγ比第７天和第１４天时略有升高，此时ＩＬ４水平与正常对照无差异。表明ＩＬ２，ＩＦＮγ的降低和ＩＬ４升高（即Ｔｈ１／Ｔｈ２的失衡）与本病存在一定关系。 This article dynamically observed changes of Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-4) in each stage of passive Heymann nephritis (PHN). The results showed that albuminuria began to appear after 7 days of administration of anti-tuberculoma antibody (TubAb) in rabbits, and IL2 and IFNγ levels were lower than those of normal controls (P <005) And IL 4 induction level began to rise; in the injection of Tub Ab on the 14th day, a large number of proteinuria, IL 4 further increased at this time with the normal control and injection of IL-4 levels were statistically significant Differences, IL  4 and proteinuria quantitative and there is a certain correlation between the 28th day when proteinuria began to decline, IL  2, IFN  7 than the 7th and 14th days when slightly elevated, then IL  4 No difference between the level and the normal control. That IL 2, IFN γ and IL 4 elevated (ie, Th1 / Th2 imbalance) and the disease there is a certain relationship.