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目的探讨分析食管癌组织中表皮生长因子受体(EGFR)的表达与上皮型钙黏附素(E-cadherin)的表达与食管癌转移的关系。方法采用免疫组织化学LSAB法对42例食管癌标本的EGFR和E-cadherin表达进行研究。结果EGFR在远处转移组和局部淋巴结转移组的表达率(分别为47.62%、56.52%)均高于相应对照组(27.08%、26.32%)(P<0.05);在组织学分级Ⅰ、Ⅱ、Ⅲ级3组中的表达率分别为16.67%、42.86%、71.43%,3组间差异有显著性(P<0.05)。E-cadherin在远处转移组和局部淋巴结转移组的表达率(分别为33.33%、26.09%)均低于相应对照组(54.17%、57.89%)(P<0.01,P<0.05);在组织学分级Ⅰ、Ⅱ、Ⅲ级3组中表达率分别为71.43%、47.62%、14.29%,3组间差异有显著性(P<0.05)。结论EGFR及E-cadherin与食管癌的浸润和转移相关。
Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and the expression of E-cadherin and the metastasis of esophageal carcinoma in esophageal cancer tissues. Methods The expressions of EGFR and E-cadherin in 42 cases of esophageal cancer specimens were studied by immunohistochemistry LSAB method. Results The positive rates of EGFR in distant metastasis group and local lymph node metastasis group were 47.62% and 56.52% respectively (27.08% and 26.32%, respectively) (P <0.05) , And the expression rates of grade Ⅲ in the three groups were 16.67%, 42.86% and 71.43%, respectively. The differences among the three groups were significant (P <0.05). The expression rates of E-cadherin in distant metastasis group and local lymph node metastasis group were 33.33% and 26.09%, respectively, lower than those in control group (54.17%, 57.89%, P <0.01, P <0.05) The expression rates of grade Ⅰ, grade Ⅱ and grade Ⅲ in three groups were 71.43%, 47.62% and 14.29%, respectively. The differences among the three groups were significant (P <0.05). Conclusion The expressions of EGFR and E-cadherin are correlated with the infiltration and metastasis of esophageal cancer.