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本文报道了1990年3月至1991年6月我室在B超监护下经腹脐静脉穿刺取胎血,为30例α地中海贫血携带者夫妇作产前诊断,手术成功率为100％,其中一次穿刺成功率为90％,无死胎及宫内感染发生。血红蛋白电泳分析检出HbBart′s水肿胎9例,占30％;轻型α地中海贫血14例,占48.67％。文中提出获取纯胎血直接作血红蛋白电泳分析,具快速、准确、可靠的优点。提出在缺乏基因诊断的条件下,该法对解决α地中海贫血的产前诊断不失为一有效手段。
This article reports from March 1990 to June 1991 my room under the super-monitoring of B-ultrasound fetal blood taken from the fetus, 30 cases of α-thalassemia carriers couples prenatal diagnosis, the success rate was 100%, of which A puncture success rate of 90%, no fetal death and intrauterine infection. Hemoglobin electrophoresis analysis detected HbBart’s edema in 9 cases, accounting for 30%; 14 cases of light α-thalassemia, accounting for 48.67%. The article proposed to obtain pure fetal blood directly hemoglobin electrophoresis analysis, with fast, accurate and reliable advantages. Proposed in the absence of genetic diagnosis of the conditions of the law to solve the prenatal diagnosis of α-thalassemia is an effective means.