论文部分内容阅读
异名 CGP-9000,Oraspor 化学名 7-[D-2-氨基-2-(1,4-环已二烯基)乙酰胺基]-3-甲氧基-3-头孢烯-4-羧酸二水合物药效分类广谱抗生素开发单位 (瑞士)Ciba Geigy 上市厂商 (日)Ciba Geigy 1982年1月首次报道 J Antibiot 29(6):653,1976 药理对革兰氏阳性和阴性菌有广谱抗菌作用,其抗菌活性与先锋霉素Ⅳ和头孢雷定相同或强2倍。在培养液和尿中的溶菌和杀菌作用,优于先锋霉素Ⅳ,因为它对青霉素结合蛋白部分的亲和性比较强。
Synonyms CGP-9000, Oraspor Chemical name 7- [D-2-amino-2- (1,4-cyclohexadienyl) acetamido] -3-methoxy-3-cephem- Acid Dihydrate Pharmacodynamic Category Broad Spectrum Antibiotic Development Unit (Switzerland) Ciba Geigy Listed Company (Day) Ciba Geigy First reported in January 1982 J Antibiot 29 (6): 653, 1976 Pharmacology Positive and negative Gram-positive Broad-spectrum antibacterial activity, its antibacterial activity and cephalosporins cephalosporin Ⅳ and cefradine the same or strong 2 times. The bacteriolytic and bactericidal action in culture broth and urine is superior to that of cephalosporin IV because of its affinity for the penicillin binding protein moiety.