肿瘤源性骨软化症是一种由恶性肿瘤引起的致残性疾病。因对本病认识不足而诊断常被延误,有的病例甚至在首发症状出现12年后才明确诊断。本病病因未明,多种肿瘤均可诱发骨软化症,但以血管外皮细胞瘤更为常见。肿瘤可发生在身体的任何部位,包括手、足、前腹壁、颈项部、副鼻窦及颅内。骨软化症往往出现在肿瘤被发现之前,所以仔细的临床检查、CT 或 BMI 扫描将有助于发现肿 Tumor-derived osteomalacia is a disabling disease caused by malignant tumors. Diagnosis is often delayed due to lack of awareness of the disease, and some cases were diagnosed only 12 years after the initial symptoms. The cause of the disease is unknown, and a variety of tumors can induce osteomalacia, but hemangiopericytoma is more common. Tumors can occur anywhere in the body, including the hands, feet, anterior abdominal wall, neck, paranasal sinus, and intracranial. Osteomalacia often occurs before the tumor is detected, so careful clinical examination, CT or BMI scans will help to find the swelling.