干燥综合征在我国一向被认为是一罕见病,1981年版实用内科学仍作如此描述。国外则认为此症是一个仅次于类风湿性关节炎(RA)的常见结缔组织病,甚至认为发病率可达1/200。本文对三年间收集的干燥综合征(SS)百余例中诊断为原发性SS者,作了有关诊断标准、临床表现、血清免疫学及其突出的合并症——肾小管酸中毒的全面分析。现分别报道如下: 诊断标准的探讨 (一)诊断标准 1981年Manthorpe综合有关资料后 Sjogren’s syndrome in our country has always been considered as a rare disease, the 1981 edition of Practical Internal Medicine is still so described. Abroad that the disease is a common second only to rheumatoid arthritis (RA) of connective tissue disease, and even that the incidence of up to 1/200. In this paper, the diagnosis of primary SS in more than one hundred cases of Sjogren’s syndrome (SS) collected in three years was made, and related diagnostic criteria, clinical manifestations, serum immunology and its prominent complications - comprehensive renal tubular acidosis analysis. Are reported separately as follows: Diagnostic criteria (a) the diagnostic criteria in 1981 Manthorpe comprehensive information