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近十年来,随着放射性同位素和免疫学等测定技术的应用,对 TSH 及其受体进行了大量的研究,并取得了突破性进展,为阐明 TSH 受体病(disease of the TSH receptor)开拓了新途径。一、TSH 和 TSH 受体TSH 是由垂体前叶嗜碱性细胞产生的分子量为28000的糖蛋白激素,由α-和β-亚基组成。TSH 的主要作用是促进甲状腺滤泡上皮细胞的生长与代谢,进而调节甲状腺激素的生物合成和释放。此外,TSH 可能对脂肪、睾丸及淋巴细胞也有影响。近年的研究表明,甲状腺细胞膜上有与 TSH 特异性结合的 TSH 受体,TSH 是通过与其受体的相互作用而发挥
In the recent ten years, with the application of the radioisotope and immunological techniques, a great deal of research has been done on TSH and its receptors and breakthroughs have been made. To elucidate the pathology of the TSH receptor A new way. TSH and TSH receptors TSH is a glycoprotein hormone produced by anterior pituitary basophils with a molecular weight of 28,000 consisting of alpha and beta subunits. The main role of TSH is to promote the growth and metabolism of thyroid follicular epithelial cells, thereby regulating thyroid hormone biosynthesis and release. In addition, TSH may also affect fat, testicles and lymphocytes. In recent years, studies have shown that thyroid cell membrane TSH-specific binding of TSH receptors, TSH through its interaction with the receptor to play