最近指出,心得安长期治疗后突然停药,有可能促使心肌梗塞和猝死。为了探讨其可能的作用机理,本文测定心绞痛病人用心得安治疗前、治疗时及治疗后的运动耐量和血小板集聚性。方法:男14例,女6例,年龄35至69岁,平均54岁。每周至少发作心绞痛3次,6个月内无不稳定型心绞痛的证据、无瓣膜性心脏病、高血压、充血性心力衰竭、慢性呼吸性肺部疾患、糖尿病、脂蛋白异常、贫血、吸烟史或心肌梗塞。血管造影显示一支或数支冠状 Recently pointed out that the sudden withdrawal of long-term treatment may cause myocardial infarction and sudden death. In order to explore its possible mechanism of action, the paper measured angina patients with propranolol before treatment, treatment and after treatment of exercise tolerance and platelet aggregation. Methods: 14 males and 6 females, aged 35 to 69 years, mean 54 years old. At least 3 episodes of angina per week, no evidence of unstable angina within 6 months, no valvular heart disease, hypertension, congestive heart failure, chronic respiratory lung disease, diabetes, lipoprotein abnormalities, anemia, smoking history Or myocardial infarction. Angiography showed one or more crowns