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本文研究模拟高原低氧下新生和胚胎大鼠发育时，下丘脑内促肾上腺皮质激素（ＣＲＦ）及垂体环磷酸腺苷（ｃＡＭＰ）水平的变化。结果表明：５ｋｍ海拔高度抑制下丘脑ＣＲＦ的发育，当发育至２５天和３０天时，ＣＲＦ含量分别为对照组的６４．８％和５７．９％。此时，体重分别为４７．８％和５２．９％。３０天时，ｃＡＭＰ为２０．８％。本研究还显示，在７ｋｍ海拔高度，已怀孕大鼠难以完成正常的妊娠和胎儿发育过程，５ｋｍ海拔高度暴露１７天时，胚胎脑内ＣＲＦ含量高于对照。
This study was designed to investigate the changes of corticotropin (cAMP) and adrenocorticotropic hormone (cAMP) in the hypothalamus of newborn and embryonic rat in simulated hypoxia. The results showed that 5 km above sea level inhibited the development of hypothalamic CRF. When developed to 25 days and 30 days, the CRF contents were 64.8% and 57.9% of the control group, respectively. At this point, the weights were 47.8% and 52.9%, respectively. At 30 days, cAMP was 20.8%. The study also showed that at 7km altitude, it is difficult for pregnant rats to complete normal pregnancy and fetal development. At 5km altitude, the content of CRF in embryonic brain is higher than that of the control.