目的:应用静息态功能磁共振成像技术,探讨抑郁障碍共病高血压患者在静息态下的脑功能损害特点。方法:共病组为30例抑郁障碍共病高血压患者,对照组为性别、年龄及受教育程度匹配的30例单纯抑郁障碍患者和30例健康被试。对所有被试进行静息状态下全脑功能磁共振扫描,采用低频振幅作为测量指标,比较三组被试的静息态脑功能差异。通过方差分析得出三组低频振幅差异有统计学意义的脑区,计算三组差异脑区的低频振幅均值并进行组间比较。结果:三组被试低频振幅差异有统计学意义的脑区包括左小脑、左舌回、右内侧额上回、右眶部额上回(P<0.05,已校正);组间比较显示共病组在左小脑和右内侧额上回的低频振幅值与抑郁障碍组差异有统计学意义(P<0.01),共病组和抑郁障碍组在左舌回和右眶部额上回的低频振幅值与健康对照组差异有统计学意义(P<0.01)。结论:本研究提示抑郁障碍共病高血压与单纯抑郁障碍患者均存在局部脑区功能异常,共病患者某些脑区异常更明显。 Objective: To investigate the characteristics of brain dysfunction under resting state in patients with comorbid depression of comorbid depression by resting state functional magnetic resonance imaging. Methods: Thirty patients with comorbid depression and co-morbid hypertension were enrolled in the comorbidity group. Thirty patients with simple depressive disorder and 30 healthy subjects who were matched by sex, age and educational attainment were enrolled. All subjects underwent whole-body functional magnetic resonance (MR) scans at rest, using low-frequency amplitude as a measure to compare resting brain function differences among the three groups. Three groups of brain regions with low amplitude differences in amplitude were obtained by ANOVA. The low frequency amplitudes of the three groups were calculated and compared between groups. Results: The brain regions of the three groups including the left cerebellum, the left lingual gyrus, the right medial frontal gyrus and the right orbital frontal gyrus were significantly different (P <0.05, corrected) There was significant difference between low frequency amplitudes of left frontal gyrus and right superior frontal gyrus in depression group and depression group (P <0.01). In the comorbidity group and depression group, There was significant difference between amplitude and healthy control group (P <0.01). CONCLUSIONS: This study suggests that there are functional abnormalities in local brain regions in patients with comorbid depression and depression, and some brain regions in comorbid patients are more abnormal.