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目的探讨凝血常规检测对于乙肝的临床诊断、治疗以及预后判断的价值。方法收集2011年1月~2013年12月中山大学附属第一医院东院收治的乙肝患者160例作为病例组,选择同期健康体检者40例作为对照组,检查2组的纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)以及活化部分凝血活酶时间(APTT),并对检查结果进行对比分析。结果轻度乙肝患者的(凝血酶时间)TT、(凝血酶原时间)PT、(纤维蛋白原)FIB与对照组比较差异无统计学意义,其对比表现为:TT(17.58±6.92)与(17.11±5.89),PT:(12.93±5.49)与(12.84±4.83),FIB:(2.81±1.05)与(2.86±0.97),中、重度乙肝以及肝硬化患者的各项指标与对照组比较差异均有统计学意义(P<0.05);APTT在病例组各型患者组间比较及与对照组之间比较差异均有统计学意义(P<0.05)。结论凝血常规与乙肝患者的肝脏损害程度具有密切关系,检测凝血常规可准确地反应乙肝病情严重程度,为临床诊断、治疗以及预后评价提供可靠依据。
Objective To investigate the value of routine coagulation tests in the diagnosis, treatment and prognosis of hepatitis B patients. Methods From January 2011 to December 2013, 160 cases of hepatitis B patients admitted from the Eastern Hospital Affiliated to the First Affiliated Hospital of Sun Yat-sen University were enrolled as the case group. Forty healthy subjects were selected as the control group during the same period, and the fibrinogen (FIB) , Prothrombin time (PT), thrombin time (TT) and activated partial thromboplastin time (APTT), and compared the test results. Results There was no significant difference in TT (prothrombin time), PT (fibrinogen) FIB (fibrinogen) between mild hepatitis B patients and controls (TT: 17.58 ± 6.92 vs 17.11 ± 5.89), PT: (12.93 ± 5.49) and (12.84 ± 4.83), FIB: (2.81 ± 1.05) and (2.86 ± 0.97), moderate and severe hepatitis B and cirrhosis patients compared with the control group (P <0.05). There was significant difference in APTT between the various types of patients in the case group and the control group (P <0.05). Conclusion The coagulation routine is closely related to the degree of liver damage in patients with hepatitis B. The detection of coagulation routine can accurately reflect the severity of hepatitis B and provide a reliable basis for clinical diagnosis, treatment and prognosis evaluation.