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研究通过Ｔ７３９小鼠接种ＬＡ７９５（小鼠肺腺癌）建立癌症恶病质动物模型，并采用康莱特对癌症恶病质鼠进行治疗，观察癌症恶病质鼠治疗后生理状况（体重、摄食量等）的改善及与癌症恶病质发生、发展相关的血清细胞因子如ＴＮＦ－α、ＩＬ－１和ＩＬ－６的水平变化。ＴＮＦ－α血清水平用ＲＩＡ检测，ＩＬ－１及ＩＬ－６用ＥＬＩＳＡ法。结果表明：与生理盐水治疗荷瘤小鼠相比，康莱特能明显阻止癌症恶病质鼠体重下降、增加其摄食量、延长生存期、延缓肿瘤生长、并使部分肿瘤液化、坏死。血清ＴＮＦ－α和ＩＬ－１水平同时也明显下降，实验所见均提示康莱特具有明显的抗癌症恶病质作用。
The animal model of cancer cachexia was established by inoculating LA795 (mice lung adenocarcinoma) in T739 mice, and Kanglaite was used to treat cancer cachexia mice, and the improvement of physiological conditions (body weight, food intake, etc.) of cancer cachexia mice after treatment was observed. The development of cancer cachexia, development of serum cytokines such as TNF-α, IL-1 and IL-6 levels. Serum levels of TNF-α were detected by RIA and IL-1 and IL-6 by ELISA. The results showed that Kanglaite can significantly reduce the weight loss, increase the food intake, prolong the survival, delay the growth of tumors, and liquefy and necrosis some tumors compared with saline-treated mice. Serum TNF-α and IL-1 levels also decreased significantly. All the findings in the experiment suggest that KLT has a significant anti-cancer cachexia effect.