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目的调查6年前发生的三甲基氯化锡中毒患者目前的健康状况。方法整群抽取居住在同一村庄的原三甲基氯化锡中毒患者29人和对照26人作为本次研究的对象。进行问卷调查和神经内科检查,测定与贫血、肝功能、甲状腺功能相关的血液生化指标和性激素水平,并测定头发中锡的含量。结果原三甲基氯化锡中毒患者残留的自觉症状主要为记忆力减退、反应速度慢、头痛、眩晕以及乏力等,原患者中膝腱反射、跟腱反射减弱人数多于对照组。血液生化检测项目以及发锡的含量在患者与对照之间差异无显著性。结论6年前的三甲基氯化锡中毒患者仍残留有对神经系统的影响,但目前血液生化指标和发锡含量未见到与当年中毒的相互关系。
Objective To investigate the current state of health of patients with trimethyltin chloride poisoning 6 years ago. Methods A total of 29 patients with original trimethyltin chloride poisoning who lived in the same village and 26 control subjects were enrolled in this study. Conduct questionnaires and neurological examinations to determine blood biochemical markers and sex hormone levels associated with anemia, liver function, thyroid function, and determine the amount of tin in the hair. Results The residual symptoms of the original trimethyltin chloride poisoned patients were mainly memory loss, slow reaction, headache, dizziness and weakness. The patients with knee tendon reflexes and Achilles tendon reflexes weakened more than the control group. The blood biochemical test items and tin content were not significantly different between patients and controls. Conclusions The patients with trimethyltin chloride poisoning 6 years ago still have some influence on the nervous system. However, there is no correlation between the blood biochemical indexes and tin content with the current poisoning.