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目的观察他汀类药物联合阿司匹林治疗脑血栓的疗效及对动脉斑块的影响。方法将160例脑血栓患者随机分为试验组和对照组各80例。2组患者均给予阿司匹林治疗,而试验组给予阿托伐他汀联合阿司匹林治疗,对比2组患者的临床治疗效果、神经功能及颈动脉斑块的改善情况。结果试验组患者的临床总有效率为91.25%明显高于对照组患者的75.00%,差异有统计学意义(t=9.072,P<0.05)。2组患者用药治疗后神经系统的功能损伤评分、颈动脉中层的厚度及动脉斑块面积得到了良好的改善和控制,试验组患者优于对照组,差异均有统计学意义(P<0.05)。结论阿托伐他汀联合阿司匹林治疗脑血栓患临床疗效显著,患者的生活质量得到了提高,值得推广应用。
Objective To observe the effect of statins combined with aspirin on cerebral thrombosis and its effect on arterial plaque. Methods 160 patients with cerebral thrombosis were randomly divided into experimental group and control group of 80 cases. Patients in both groups were given aspirin, while those in trial group were given atorvastatin combined with aspirin. The clinical effects, neurological function and carotid plaque were compared between the two groups. Results The total clinical effective rate of the experimental group was 91.25%, which was significantly higher than that of the control group (75.00%), the difference was statistically significant (t = 9.072, P <0.05). The scores of functional impairment, the thickness of middle carotid artery and plaque area of the two groups were improved and controlled after treatment. The patients in the test group were better than the control group (P <0.05) . Conclusion Atorvastatin combined with aspirin treatment of cerebral thrombosis clinical significant effect, the quality of life of patients has been improved, it is worth promoting the application.