Janus激酶/信号转导蛋白和转录激活蛋白(JAK/STAT)是近年来发现的一种细胞内信号转导途径,与许多激素、生长因子、细胞因子和基因特殊转录活化的作用相关。JAK/STAT途径由一系列特殊的蛋白与蛋白相互作用构成,从而导致核内特殊的蛋白与DNA相互作用。在细胞因子作用下JAK被磷酸化和激活,随后活化的JAK使转录因子中的 Janus kinase / signal transducer and activator of transcription (JAK / STAT) is an intracellular signal transduction pathway found in recent years and is associated with the role of many transcriptional activators of hormones, growth factors, cytokines and genes. The JAK / STAT pathway consists of a series of specific protein-protein interactions that result in the interaction of specific proteins in the nucleus with DNA. JAKs are phosphorylated and activated by cytokines and subsequently activated JAKs make transcriptional factors