论文部分内容阅读
目的观察沙格列汀联合二甲双胍对初发2型糖尿病胰岛素抵抗的改善作用。方法将76例初发2型糖尿病患者随机分为两组,对照组38例给予二甲双胍单药治疗,观察组38例给予二甲双胍与沙格列汀联合治疗,比较两组治疗效果。结果治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数水平均显著降低,胰岛素分泌指数、空腹胰岛素水平均显著升高,且观察组改善程度大于对照组,差异有统计学意义(P<0.05)。结论沙格列汀与二甲双胍联合治疗初发2型糖尿病效果理想,可有效控制血糖,改善胰岛素抵抗。
Objective To observe the effect of saxagliptin and metformin on insulin resistance in newly diagnosed type 2 diabetic patients. Methods 76 patients with newly diagnosed type 2 diabetes mellitus were randomly divided into two groups. The control group was treated with metformin monotherapy, and the observation group with metformin and saxagliptin combined treatment. The treatment effect was compared between the two groups. Results After treatment, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, insulin resistance index were significantly lower, insulin secretion index and fasting insulin levels were significantly increased, and the observation group improved more than the control group, the difference was statistically significant Significance (P <0.05). Conclusion Saxagliptin combined with metformin is an effective treatment for newly diagnosed type 2 diabetes, which can effectively control blood sugar and improve insulin resistance.