目的　确定丝氨酸 /精氨酸蛋白激酶 (SRPK)在人类染色体上的区位。方法　运用Southern印迹杂交及荧光原位杂交技术。结果　SRPK1定位于人类染色体 6p 2 1.2 -p 2 1.3 ,SRPK2 定位于人类染色体 7q2 2 - q2 3 .1。结论　为进一步研究SRPK1的生物学功能以及与人类疾病的关联提供理论依据 Objective To determine the location of serine / arginine protein kinase (SRPK) on the human chromosome. Methods Southern blotting and fluorescence in situ hybridization were used. Results SRPK1 was mapped on human chromosome 6p 2 1.2 -p 2 1.3 and SRPK2 was mapped on human chromosome 7q2 2 - q2 3 .1. Conclusion To provide a theoretical basis for further study on the biological function of SRPK1 and its association with human diseases