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目的通过我院风湿科63例白塞病(BD)伴有葡萄膜炎患者了解其人口和临床特征、眼部表现、视力预后及治疗状况。方方法法回顾性分析我科2004年1月～2008年12月期间BD伴有葡萄膜炎患者63例(109眼)住院患者,分析患者的年龄、性别、葡萄膜炎类型、眼部发病年龄及病程、视力、系统受累及治疗状况。结果63例患者中51例(81%)是男性,12例(19%)是女性。葡萄膜炎发病的平均年龄28.5岁(男性)和36.4岁(女性)。眼部受累双侧为73%和单侧27%。全葡萄膜炎在男女中是最常见的类型。眼底病变及威胁视力状况更常见于男性。在初次就诊时,潜在视力小于或等于0.1男性是22.9%,女性是3.7%。大剂量激素联合免疫抑制剂治疗后63例(109眼)眼部症状好转。结论BD伴有的葡萄膜炎常在30岁左右发作,男性为多,损害男性视力比女性高。大剂量激素联合免疫抑制剂治疗短期内可有效改善葡萄膜炎症状。
Objective To understand the demographic and clinical features, ocular manifestations, prognosis and treatment of 63 Behcet’s disease patients with rheumatoid arthritis in our hospital. Methods: A retrospective analysis of 63 patients (109 eyes) hospitalized with BD with uveitis from January 2004 to December 2008 in our department was performed. The age, sex, type of uveitis, age of onset of eye And course of disease, visual acuity, systemic involvement and treatment status. Results Of the 63 patients, 51 (81%) were males and 12 (19%) were females. The average age of onset of uveitis was 28.5 years (men) and 36.4 years (females). Ocular involvement was 73% on both sides and 27% on one side. Uveitis is the most common type in both men and women. Fundus lesions and threatening visual acuity are more common in men. At initial visit, potential vision was less than or equal to 0.1 for men and 22.9% for women and 3.7% for women. After the treatment of high-dose hormone combined with immunosuppressive agents, 63 cases (109 eyes) of ocular symptoms improved. Conclusion BD associated with uveitis often attack around the age of 30, more men, impairing male visual acuity than women. High-dose hormones combined with immunosuppressive agents in the short term can effectively improve the symptoms of uveitis.