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心血管疾病是2型糖尿病患者的主要死亡原因之一。新近研究发现胰高血糖素样肽-1(GLP-1)不仅通过葡萄糖依赖的方式刺激胰岛素分泌和抑制糖原的不适当分泌,延缓胃排空,增加饱食感等方式调节血糖;还能通过GLP-1R和受体以外的方式发挥心血管保护作用,包括心肌、内皮细胞和血管等。越来越多的动物和临床研究显示,GLP-1和GLP-1R激动剂都能改善内皮细胞功能、促进钠的排泄、改善缺血损伤的心肌和心功能的恢复,减少心血管风险的危险因素和标志物。文中综述有关动物和人类研究中GLP-1对心血管系统的作用以及可能机制。
Cardiovascular disease is one of the leading causes of death in people with type 2 diabetes. Recent studies have found that glucagon-like peptide-1 (GLP-1) not only regulates insulin secretion in a glucose-dependent manner, but also inhibits inappropriate secretion of glycogen, delays gastric emptying and increases satiety, Through the GLP-1R and receptor other than cardiovascular protection, including myocardial, endothelial cells and blood vessels. A growing number of animal and clinical studies have shown that both GLP-1 and GLP-1R agonists improve endothelial function, promote sodium excretion, improve myocardial and cardiac function recovery from ischemic injury, and reduce the risk of cardiovascular risk Factors and markers. The article reviews the role of GLP-1 in cardiovascular and cardiovascular systems in animal and human studies as well as possible mechanisms.