蛋白质的可逆磷酸化修饰是生物体内普遍存在的信息转导调节方式,几乎参与生命活动的所有过程,在细胞的增殖、发育和分化,细胞信号转导、转录和翻译,细胞的周期调控、蛋白降解和新陈代谢,细胞生存、细胞凋亡和肿瘤发生等方面发挥着重要的作用。目前已知许多人类疾病的发生都与异常的蛋白质磷酸化修饰有关,而且一 Reversible phosphorylation modification of protein is a universal information transduction and regulation mode in organism, which is involved in almost all processes of life activities, such as cell proliferation, development and differentiation, cell signal transduction, transcription and translation, cell cycle regulation, protein Degradation and metabolism, cell survival, apoptosis and tumorigenesis plays an important role. It is known that many human diseases are associated with aberrant phosphorylation of proteins and that one