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为探讨细胞因子在急性心肌梗塞（AMI）中的作用，测定了28例AMI患者血清肿瘤坏死因子α（TNFα）和白细胞介素1β（IL－β）水平，并选择13例不稳定型心绞痛（UA）患者和15例健康人作为对照。结果表明：AMI组血清TNFα水平明显高于UA组及正常组（P＜0．01），UA组血清TNFα水平明显高于正常组（P＜0．01）；血清IL－1β水平在严重的AMI患者（心功能KillipⅢ、Ⅳ级）明显高于正常组（P＜0．01）。提示血清TNFα和IL-1β水平与心肌缺血的严重程度有关。
To investigate the role of cytokines in acute myocardial infarction (AMI), serum levels of tumor necrosis factor α (TNFα) and interleukin-1β (IL-β) were measured in 28 AMI patients and 13 patients with unstable angina pectoris UA) patients and 15 healthy people as control. The results showed that serum TNFα level in AMI group was significantly higher than that in UA group and normal group (P <0.01), serum TNFα level in UA group was significantly higher than that in normal group (P <0.01), serum IL-1β level was significantly AMI patients (Killip Ⅲ, Ⅳ grade) were significantly higher than the normal group (P <0.01). Tip serum TNFα and IL-1β levels and the severity of myocardial ischemia.