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目的：调查药剂人员对临床合理用药知识的掌握情况，对药剂人员进行临床合理用药知识干预，以提高临床用药的合理化和有效性。方法选取该院未进行临床合理用药干预的药剂人员监测的120份门诊处方作为对照组，选取进行临床合理用药干预的药剂人员监测的120份门诊处方作为观察组，比较2组处方合格率。结果观察组处方合格率为95．8％（115／120）显著高于对照组的62．5％（75／120），差异有统计学意义（χ2＝16．583，P＜0．05）。结论对药剂人员进行临床合理用药知识干预，可有效促进临床用药的科学合理化，保障患者用药安全，值得临床推广普及。“,”Objective To analysis the master situation of clinical rational drug in pharmacy staff .Methods Selected 120 outpatient prescriptions with no rational drug use intervention by pharmacy staff as control group .Selected 120 outpatient prescriptions with rational drug use intervention by pharmacy staff as observation group .Compared the pass rate of 2 groups. Results The pass rate of observation group (95.8%,115/120)was higher than that of control group (62.5%,75/120),the difference was statistically significant (χ2 =16.583,P<0.05).Conclusion Rational drug use intervention on pharmacy staff can effectively promote the scientific rationalization of clinical medicine ,guarantee drug safety of patients ,worthy of populari-zing.