肿瘤化疗失败的重要原因是肿瘤在多次化疗后产生多药耐药(multidrug resistance,MDR),导致肿瘤细胞对一种化学药物产生耐药的同时,对结构和作用机制不同的多种抗肿瘤药物产生交叉耐药性。MDR的产生与P-糖蛋白(P-glycoprotein,P-gp)关系密切。研究表明,P-gp不仅在肿瘤细胞膜上表 An important reason for tumor chemotherapy failure is that tumors produce multidrug resistance (MDR) after multiple chemotherapies, causing tumor cells to become resistant to one chemotherapeutic drug. Meanwhile, many antitumor agents with different structures and mechanisms of action Drugs produce cross-resistance. The production of MDR is closely related to P-glycoprotein (P-gp). Studies have shown that P-gp not only in the tumor cell membrane on the table