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观察联合用药对实验性家兔海水型肺水肿的呼吸混沌动力学特性影响,用2 mg/kg海水通过肺支气管灌注复制海水肺水肿模型。用东莨菪碱(0.06 mg/kg)、氨茶碱(50 mg/kg)、纳络酮(0.08 mg/kg)耳缘静脉注射治疗肺水肿。0.9％NaCl静脉注射(4.2 ml/kg)作为药物对照组。用生理信号计算机采集系统对数据进行实时采集。正常家兔呼吸Lyapunov指数L1=0.060 10±0.099 43((?)±s),海水型肺水肿L1=3.76 41±2.94 89((?)±s)。呼吸时间序列数据二维、三维混沌空间散点图显示海水型肺水肿的混沌吸引子空间结构较正常发生改变,用药后L1值和混沌图部分接近正常,混沌动力学分析方法可以应用于肺水肿早期诊断及药物治疗效果的评价。
The effects of combination therapy on respiration chaotic dynamics of experimental rabbits with seawater pulmonary edema were observed. The seawater pulmonary edema model was replicated by pulmonary bronchial perfusion with 2 mg / kg seawater. Pulmonary edema was treated with scopolamine (0.06 mg / kg), aminophylline (50 mg / kg) and naloxone (0.08 mg / kg) 0.9% NaCl intravenous injection (4.2 ml / kg) as a drug control group. Using physiological signal computer acquisition system to collect data in real time. The Lyapunov exponent of normal rabbits L1 = 0.060 10 ± 0.099 43 (± s ± s), seawater pulmonary edema L1 = 3.76 41 ± 2.94 89 ((±) ± s). The spatial structure of the chaotic attractor in seawater-based pulmonary edema shows a more normal change in the 2D and 3D chaos spatial scatter plots of respiration time series data. The values of L1 and chaotic maps are close to normal after treatment, and chaotic dynamic analysis can be applied to pulmonary edema Early diagnosis and evaluation of drug treatment.