药品是人们用于预防、诊断、治疗疾病的物质,药品质量的好坏影响着人们用药的安全有效。由于外界环境的影响和药品自身的性质决定了药品质量的不稳定性。药品质量的不稳定性包括化学、生物、物理不稳定性。本文阐述的“糖衣龟裂”现象是由物理变化引起的不稳定性。这种变化虽然只表现在药品外观质量的异常,但同时也伴随着化学变化, Medicines are substances that people use to prevent, diagnose and treat diseases. The quality of medicines affects people’s safety and effectiveness. Due to the external environment and the nature of the drug itself determines the instability of the quality of the drug. The instability of drug quality includes chemical, biological, and physical instability. The “sugar cracked” phenomenon described in this article is the instability caused by physical changes. Although this change is only manifested in the abnormal appearance of the quality of drugs, but also accompanied by chemical changes,