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目的:探讨在静脉输液通道无法建立的情况下,单纯腹腔复苏对创伤失血性休克是否有效。方法:40只SD大鼠被随机分为A组(空白对照组)、B组(休克不复苏组,出血+急救期不接受任何治疗)、C组(腹腔复苏组,出血+急救期给予腹腔注射平衡液10ml/100g体重)、D组(静脉输液组,出血+急救期静脉输入平衡液并保持大鼠MAP在60±5mmHg),B、C、D三组大鼠均制备为未控制创伤失血性休克模型,记录各组大鼠的生存时间,比较各组大鼠的生存率,在0、30、90和120min时相点观察比较各组大鼠临床指标、血气分析指标和血清TNF-α。结果:C组大鼠的存活时间较B组明显延长(P<0.05);C组大鼠72h存活率明显高于B组,但低于D组(P<0.05)。C组大鼠的临床复苏指标、血气分析指标均优于B组,但较D组差;C组大鼠血清TNF-α低于B组,高于D组。C组大鼠生存率明显高于B组,低于D组。结论:腹腔复苏治疗创伤失血性休克大鼠是有效的但效果比静脉复苏差。
OBJECTIVE: To investigate whether simple peritoneal resuscitation is effective for traumatic hemorrhagic shock in the condition that intravenous infusion can not be established. Methods: Forty SD rats were randomly divided into group A (blank control group), group B (shock not resuscitation group, bleeding + first aid period without any treatment), group C (abdominal cavity resuscitation group, bleeding + first aid period) Injection equilibrium solution 10ml / 100g body weight), D group (intravenous infusion group, bleeding + first aid intravenous infusion solution and keep the rat MAP 60 ± 5mmHg), B, C, D three groups of rats were prepared for uncontrolled trauma The hemorrhagic shock model was used to record the survival time of rats in each group. The survival rates of rats in each group were compared. The clinical indexes, blood gas analysis indexes and serum TNF-α levels were observed at 0, 30, 90 and 120 minutes. α. Results: The survival time of group C was significantly longer than that of group B (P <0.05). The survival rate of group C at 72 h was significantly higher than that of group B but lower than that of group D (P <0.05). The clinical recovery index and blood gas analysis index of group C were better than group B, but worse than group D. The serum level of TNF-α in group C was lower than that of group B and higher than that of group D. The survival rate of group C was significantly higher than that of group B, lower than that of group D. CONCLUSION: Intraperitoneal resuscitation is effective in traumatic hemorrhagic shock in rats, but its effect is worse than that of vein resuscitation.