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目的观察通窍鼻炎颗粒对大鼠的长期毒性。方法分别给予大鼠49.0、24.5、12.3 g(药材).kg.d-1通窍鼻炎颗粒,ig给药,连续6个月,停药后观察2周。分别测量大鼠的体重,计算脏器的系数,测定血液学和血液生化学的指标,并做组织病理学检查。结果通窍鼻炎颗粒给药组大鼠的外观体征、行为活动、体重、脏器系数、血液学和血液生化学指标与正常对照组比较,均无明显差异;病理检查未见与药物毒性相关的明显病变,停药后也未见药物延迟性毒性反应。结论长期给予大鼠通窍鼻炎颗粒无明显毒性,推论临床拟用剂量安全。
Objective To observe the long-term toxicity of Tongqiao Biyan Granules on rats. Methods The rats were given 49.0, 24.5, 12.3 g (medicinal herbs).kg.d-1 Tongqiao rhinitis granules respectively and administered ig for 6 months. Observed after stopping for 2 weeks. The rats’ body weights were measured, the organ coefficients were calculated, hematology and blood biochemistry were measured, and histopathological examinations were performed. RESULTS: The appearance, behavior, body weight, organ coefficient, hematology and blood biochemical indexes of rats in Tongfu Biyan Granule group had no significant difference compared with the normal control group; pathological examination showed no obvious correlation with drug toxicity. No toxic delayed drug reaction was observed after drug withdrawal. Conclusion Long-term administration of Tongqiao rhinitis granules has no obvious toxicity, and it is deduced that the proposed dose is safe.