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目的研究上皮钙粘素(E-cadherin,E-cad)和β连接素(β-catenin,β-cat)在滑膜肉瘤组织中的表达特征及预后意义。方法应用免疫组化方法检测E-cad和β-cat在60例滑膜肉瘤组织中的表达情况,分析其与临床病理特征及患者术后生存时间的关系。结果 E-cad和β-cat的阳性表达率分别为28.3%(17/60)和23.3%(14/60);β-cat异常表达率为45%(27/60)。两者的表达均与滑膜肉瘤的病理学分型及组织学分级有关,β-cat的异常表达还与患者肿瘤部位、TNM分期及转移有关(P<0.05)。E-cad和β-cat表达组的生存情况明显优于β-cat异常表达组(P<0.05)。结论细胞黏附因子E-cad表达下调及β-cat的异常表达提示肿瘤细胞间的黏附力减弱、运动能力加强,肿瘤复发转移潜能增强,患者预后不良。
Objective To investigate the expression and prognostic significance of E-cadherin and β-catenin in synovial sarcoma. Methods The expression of E-cad and β-cat in 60 cases of synovial sarcoma was detected by immunohistochemistry. The relationship between E-cad and β-cat in the pathological features and the survival time were analyzed. Results The positive rates of E-cad and β-cat were 28.3% (17/60) and 23.3% (14/60), respectively. The abnormal expression rate of β-cat was 45% (27/60). The expression of both was related to the pathological type and histological grade of synovial sarcoma. The abnormal expression of β-cat was also related to the tumor location, TNM stage and metastasis (P <0.05). The survival of E-cad and β-cat expression group was significantly better than that of β-cat abnormal expression group (P <0.05). Conclusions The down-regulation of E-cadherin and abnormal expression of β-cat suggest that the adhesion between tumor cells is weakened, the motor ability is strengthened, the potential of tumor recurrence and metastasis is enhanced, and the prognosis is poor.