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目的对喉非霍奇金淋巴瘤（ＬＮＨＬ）这一罕见病变临床病理学特点进行观察，并对其病理诊断、起源组织及与ＥＢＶ感染的关系作一初步探讨。方法复习１８ａ间９例喉ＮＨＬ病理存档资料及临床资料，用免疫组化方法进行病理分型及观察。结果９例均表现为渐进性声嘶伴憋气，６例以呼吸困难急症入院。组织学上多形Ｔ细胞淋巴瘤５例，Ｂ细胞淋巴瘤４例，其中淋巴浆细胞样型和小细胞性各２例。２例Ｂ淋巴瘤作ＥＢＶ免疫组化染色，结果均为阳性。９例中５例确认为喉原发淋巴瘤，２例为上呼吸道多灶病变。结论ＬＮＨＬ中高度恶性的多形Ｔ淋巴瘤超过半数，区分ＬＮＨＬ免疫亚型并探讨其播散方式及与ＥＢＶ感染的关系很有必要。
Objective To observe the clinicopathological characteristics of the rare lesion of non-Hodgkin’s lymphoma (LNHL), and to make a preliminary study on its pathological diagnosis, origin tissue and relationship with EBV infection. Methods The pathological archival data and clinical data of 9 cases of laryngeal NHL were reviewed during 18 years. Pathological classification and observation were performed by immunohistochemistry. Results All cases showed progressive hoarseness with hernia, and 6 cases were hospitalized with dyspnea. Histologically, there were 5 cases of pleomorphic T-cell lymphoma, 4 cases of B-cell lymphoma, 2 cases of lymphoplasmacytic type and 2 cases of small cell. Two cases of B lymphoma were stained for EBV immunohistochemistry and the results were all positive. Of the 9 cases, 5 cases were identified as primary lymphoma of the larynx, and 2 cases were multifocal lesions of the upper respiratory tract. Conclusion More than half of the highly malignant polymorphic T lymphomas in LNHL are distinguished. It is necessary to distinguish LNHL immune subtypes and to explore their relationship with EBV infection.