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目的探讨奥沙利铂(L-OPH)联合5-氟脲嘧啶(5-FU)、亚叶酸钙(CF)治疗晚期直肠癌的近期疗效。方法 L-OPH100mg/m2,静脉滴注2h,第1天;CF200mg/m2,静脉滴注2h后滴注5-Fu400mg/m2,后续5-Fu500mg/m2,静脉持续输注22h,第1-5天。每3周为一个周期,每两周期评定一次疗效,本组均治疗4个周期以上。结果本组完全缓解(CR)3例(占5.9%),部分缓解(PR)22例(占43.1%),稳定(SD)16例(占31.4%),进展(PD)10例(占19.6%),总有效率49.0%。不良反应主要包括神经毒性,恶心、呕吐、腹泻、骨髓抑制、口腔溃疡、肝功能异常、便秘等。除2例骨髓抑制为Ⅲ度外,其他均为Ⅰ～Ⅱ度。未见肝肾功能和心脏损害,无治疗相关性死亡患者及因毒性反应而延缓化疗者。结论奥沙利铂联合5-氟脲嘧啶、亚叶酸钙具有疗效肯定,不良反应轻、患者可耐受、安全性较好等特点,是晚期直肠癌患者的有效化疗方案。
Objective To investigate the short-term curative effect of oxaliplatin (L-OPH) combined with 5-fluorouracil (5-FU) and leucovorin (CF) Method L-OPH100mg / m2, intravenous infusion 2h, on the first day; CF200mg / m2, intravenous drip 2h after infusion of 5-Fu400mg / m2, follow-up 5-Fu500mg / m2, intravenous infusion of 22h, 1-5 day. Every 3 weeks for a cycle, assess the efficacy of every two cycles, the group were treated for more than 4 cycles. Results The complete remission (CR) was achieved in 3 cases (5.9%), partial remission (PR) in 22 cases (43.1%), stable (SD) in 16 cases (31.4%) and progress (PD) in 10 cases %), The total efficiency of 49.0%. Adverse reactions include neurotoxicity, nausea, vomiting, diarrhea, myelosuppression, oral ulcers, liver dysfunction, constipation and so on. Except for 2 cases, the degree of myelosuppression was Ⅲ degree, others were grade Ⅰ ~ Ⅱ. No liver and kidney function and heart damage, no treatment-related death patients and delayed chemotherapy due to toxicity. Conclusion Oxaliplatin combined with 5-fluorouracil and leucovorin are effective chemotherapy in patients with advanced colorectal cancer with definite therapeutic effect, mild adverse reactions, tolerable patients and good safety.