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目的：观察和分析静脉注射丙种球蛋白(IVIG)无反应性川崎病（kawasa kidisease，KD）的发生率及临床特点，为静脉注射丙种球蛋白的治疗无反应性川崎病效果提供一定的参考借鉴。方法：选取2009年6月到2014年6月我院收治的130例KD患儿的临床资料，按照静脉注射丙种球蛋白的反应情况分为IVIG敏感组和无反应组，比较两组的临床特点。结果：通过临床治疗和观察分析，诊断为川崎病并接受IVIG治疗患儿130例，其中IVIG敏感者105例，无反应者25例，发生率19.23%(25/130)。无反应组接受IVIG治疗时间早，发热时间长，住院时间长、中性粒细胞比值、CRP明显高于敏感组，而血浆白蛋白明显低于敏感组。IVIG无反应组合并冠状动脉病变9例(36.00%)，明显高于IVIG敏感组13例(12.38%)。对IVIG无反应者的再治疗，给予IVIG追加疗法，甲基泼尼松龙冲击治疗，泼尼松口服治疗。结论：IVIG无反应性川崎病与IVIG敏感性川崎病患者相比，更容易发生冠状动脉病变和严重并发症；接受IVIG治疗时间、发热时间、中性粒细胞比值、CRP，血浆白蛋白是IVIG无反应的危险因素。对IVIG无反应性川崎病可以用IVIG追加治疗，值得临床推广应用。“,”Objective: To observe and analysis the intravenous immunoglobulin (IVIG) nonreactive Kawasaki disease (Kawasaki disease, KD) of the incidence and the clinical features, treatment with intravenous gamma globulin non reactive Kawasaki il effect to provide certain reference. Methods: the clinical data of 130 cases of KD were selected from 2009 June to 2014 June in our hospital were, in accordance with the reactions of intravenous gamma globulin is divided into IVIG sensitive and non reactive groups, the clinical characteristics of the two groups were compared. Results: by analyzing the clinical treatment and observation, diagnosis and Kawasaki disease treated by IVIG in 130 cases, including 105 cases of IVIG sensitive subjects, 25 cases of non responders, the incidence was 19.23% (25/130). Non response group received IVIG treatment time, long heating time, duration of hospitalization, the ratio of neutrophils, CRP was significantly higher than that of sensitive group, while plasma albumin was significantly lower than that of sensitive group. IVIG non response group and 9 patients with coronary artery disease (36.00%), significantly higher than that of IVIG sensitive group 13 cases (12.38%). Re treatment non response to IVIG, give the IVIG additional therapy treatment, methylprednisolone, prednisone treatment. Conclusion: IVIG unresponsiveness Kawasaki disease and IVIG sensitivity compared with patients Kawasaki disease, are more likely to have coronary artery disease and severe complications; receiving IVIG treatment time, heating time, the ratio of neutrophils, CRP, plasma albumin is a risk factor for IVIG no response. The IVIG non reactive Kawasaki disease can use IVIG additional treatment, worthy of clinical application.