建立具有中医特点并能够进行中医证候分型的实验动物模型是制约中药新药开发过程中药理学研究的瓶颈问题。黄褐斑是一种常见的影响面部美容的疾病,如何建立符合中医辨证论治用药特点的黄褐斑肝郁证模型是研发治疗该病证新药的关键。文章简述了近年来关于黄褐斑小鼠模型建立方法,从中尝试寻求建立黄褐斑肝郁证小鼠 The establishment of experimental animal model with Chinese characteristics and being able to type TCM syndromes is a bottleneck restricting pharmacological research during the development of new Chinese medicine. Chloasma is a common facial cosmetic disease, how to establish consistent with traditional Chinese medicine treatment of melasma melatonin syndrome model is the key to the development of new drugs to treat the disease. This article briefly describes the method of establishing a mouse model of melasma in recent years, and tries to seek for the establishment of mice with melasma