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涎泪腺炎病毒已鉴定为实验大鼠的病原体之一（简称ＳＤＡＶ）。鼻内接种２ｄ内可引起鼻炎。唾液腺、泪腺小管和腺泡上皮坏死。临床上表现为隐性感染的ＳＤＡＶ，感染可导致宿主的一时性的兔疫功能低下。本实验将ＡＨ６６腹水型肝癌细胞接种给感染ＳＤＡｖ和未感染ＳＤＡＶ大鼠，以期观察ＳＤＡＶ感染对ＡＨ６６癌细胞存活性和荷瘤大鼠细胞免疫的影响．５０只（雌性、ＳＰＦ、近交系、６周龄）Ｄｏｎｒｙｎ大鼠被接种ＳＤＡＶ和ＡＨ６６癌细胞。采用组织病理学，血清学，血中Ｔ细胞亚群分析等实验方法。结果ＡＨ６６癌细胞在ＳＤＡＶ感染组大鼠肺内的存活率（９０％）明显高于未感染ＳＤＡＶ组（４０％），血中Ｔ细胞亚群在ＳＤＡＶ感染组ＣＤ４平均值的比值低于对照组。ＡＨ６６癌细胞接种组ＣＤ４平均值的比值高于ＳＤＡＶ＋ＡＨ６６癌细胞接种组。同时ＳＤＡＶ感染＋ＡＨ６６癌细胞接种组的ＣＤ４／ＣＤ８的比值明显增大并倒置。以上的结果表明ＳＤＡＶ感染后，病毒干扰宿主细胞免疫功能从而对ＡＨ６６癌细胞有促增殖作用。
Salivary lacrimal gland virus has been identified as one of the pathogens of experimental rats (SDAV for short). Intranasal inoculation within 2d can cause rhinitis. Salivary gland, lacrimal gland ductal epithelium and acinar necrosis. Clinically manifested as a recessive infection of SDAV, the infection can lead to temporary host of the host immune function. In this study, AH66 ascites hepatoma cells were inoculated into SDAv infected and untreated SDAV rats in order to observe the effects of SDAV infection on the viability of AH66 cancer cells and the cellular immunity of tumor-bearing rats. Fifty (female, SPF, inbred, 6 weeks old) Donryn rats were vaccinated with SDAV and AH66 cancer cells. Using histopathology, serology, blood T cell subsets analysis and other experimental methods. Results The survival rate (90%) of AH66 cells in the lung of SDAV-infected rats was significantly higher than that of the non-infected SDAVs (40%). The mean CD4 of CD4 + T cells in SDAV-infected group was lower than that of the control group . AH66 cancer cell inoculation group average CD4 ratio was higher than the SDAV + AH66 cancer cell inoculation group. At the same time, the ratio of CD4 / CD8 of SDAV infection + AH66 cancer cell inoculation group was significantly increased and inverted. The above results indicate that after virus infection of SDAV, the virus interferes with the immune function of the host cells and thus promotes the proliferation of AH66 cancer cells.