哮喘的发病机理迄今未完全阐明。近年来人们认识到气道炎症是哮喘的基础病理改变和发病机理的中心环节,由此而引发气道高反应性和气道阻塞,从而出现一系列的临床症状。中性粒细胞(PMN)是人类主要的炎症细胞之一。体外研究表明它的激活、肺浸润均与气道高反应性密切有关。为此, The pathogenesis of asthma has not been fully elucidated so far. In recent years, people have realized that airway inflammation is the central link of the basic pathological changes and pathogenesis of asthma, which lead to airway hyperresponsiveness and airway obstruction, resulting in a series of clinical symptoms. Neutrophils (PMNs) are one of the major human inflammatory cells. In vitro studies have shown that its activation, pulmonary infiltrates are closely related with airway hyperresponsiveness. to this end,