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以家蝇为材料，研究了增效剂ＮＩＡ１６３８８（简称ＮＩＡ）对其的毒理作用。结果表明，ＮＩＡ对家蝇具有相当高的毒性，这是ＮＩＡ对多个靶标位点综合作用的结果。ＮＩＡ可抑制羧酸酯酶的活性，Ｉ５０值为（２．４１±０．７５）×１０－６ｍｏｌ／Ｌ（α－ＮＡ），（６．４９±２．０４）×１０－８ｍｏｌ／Ｌ（β－ＮＡ）；ＮＩＡ为４．２０×１０－４ｍｏｌ／Ｌ时，对多功能氧化酶的抑制率高达（９８．３５±２．４０）％。ＡＣｈＥ对ＮＩＡ十分敏感，Ｉ５０值为（２．２９±０．７９）×１０－７ｍｏｌ／Ｌ。ＮＩＡ对神经突触体ＡＴＰａｓｅ有一定的抑制作用。
Housefly as a material, the synergist NIA16388 (referred to as NIA) on its toxicological effects. The results show that NIA has a very high toxicity to house flies, which is the result of the combined effect of NIA on multiple target sites. NIA inhibited carboxylesterase activity with I50 values of (2.41 ± 0.75) × 10-6 mol / L (α-NA) and (6.49 ± 2.04) × 10-8 mol / L β-NA). When NIA was 4.20 × 10-4 mol / L, the inhibitory rate of multifunctional oxidase reached as high as (98.35 ± 2.40)%. AChE is very sensitive to NIA, I50 value (2.29 ± 0.79) × 10-7mol / L. NIA has a certain inhibition of neurosynaptic ATPase.