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为了阐明过氧化低密度脂蛋白（ＯＸ－ＬＤＬ）能否引起家兔体内脑动脉粥样硬化的形成，以及该物质对血浆脂蛋白ＬＤＬ（ＰｌａｓｍａＬｏｗＤｅｎｓｉｔｙＬｉｐｏｐｒｏｔｅｉｎ）脂质生化学和其分子超微结构的影响。分以下３组，即生理盐水对照组、正常ＬＤＬ（Ｎ－ＬＤＬ）组以及脂质过氧化ＬＤＬ（ＯＸ－ＬＤＬ）组，用一定量的上述液体分别注射各自的家兔耳静脉内，每日１次，共５周。发现Ｎ－ＬＤＬ组与对照组，血浆中ＬＰＯ和ＡｐｏＢ的含量以及血浆ＬＤＬ分子颗粒和脑动脉超微结构均未见明显变化，而ＯＸ－ＬＤＬ组不仅血浆中ＬＰＯ和ＡｐｏＢ含量经周逐渐增加，血浆ＬＤＬ分子颗粒也逐渐增大，脑动脉粥样硬化形成也很明显。说明ＯＸ－ＬＤＬ是引起体内脑动脉硬化形成的原因之一。
In order to clarify whether OX-LDL can induce the formation of cerebral atherosclerosis in rabbits and the effect of this substance on lipid biochemistry and ultrastructure of plasma lipoprotein lipoprotein (LDL) . The following three groups were divided into normal saline control group, normal LDL (N-LDL) group and lipid peroxidation LDL (OX-LDL) group. Each group was given a certain amount of the above- 1 time, a total of 5 weeks. No significant changes were found in the contents of LPO and ApoB in plasma and in the ultrastructure of LDL particles and cerebral arteries in N-LDL group and control group. In the OX-LDL group, LPO and ApoB contents in plasma were increased gradually, Plasma LDL molecules also gradually increase the particle size, cerebral atherosclerosis is also very obvious. OX-LDL is one of the reasons causing the formation of cerebral arteriosclerosis in vivo.