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目的探讨 NKG2D-MICA/B 在急性白血病肿瘤免疫逃逸机制中的作用。方法选择20例初发未治疗的急性白血病患者。流式细胞术检测白血病细胞表面 MICA/B 表达水平、ELISA 法检测血清可溶性 MICA 及 MICB 水平,同时检测患者 NK 细胞活化性受体 NKG2D 表达水平。5名健康人作对照。结果 (1)20例急性白血病患者中有18例患者白血病细胞表面表达 MICA/B,但是在一个较低的
Objective To investigate the role of NKG2D-MICA / B in the immune escape mechanism of acute leukemia. Methods Twenty patients with newly diagnosed untreated acute leukemia were selected. The expression of MICA / B on leukemia cells was detected by flow cytometry. The levels of soluble MICA and MICB were detected by ELISA. The expression of NKG2D was also detected. 5 healthy people as a control. Results (1) MICA / B was expressed on leukemic cells in 18 of 20 patients with acute leukemia, but in a lower