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抗病毒药物的研发是现今药物开发的热点,也是难点。分析抗病毒药物研发的关键性困难和障碍,在生物合成药物学、天然药物的生物转化学、药物设计学、免疫学、病毒学等学科知识基础上,借鉴组合化学、组合生物催化、高通量筛选等当今较前沿的药物研发途径和技术,提出了“组合微生物转化”的研发理念和相应途径,以应用于天然抗病毒药物的研发和药理毒理改造。
R & D of antiviral drugs is a hot and difficult point of drug development nowadays. Based on the knowledge of biosynthesis pharmacology, biotransformation of natural medicine, drug design, immunology, virology and other disciplines, we can learn about the key difficulties and obstacles in the development of antiviral drugs, such as combinatorial chemistry, combinatorial biocatalysis, Qualcomm Volume screening and other current cutting-edge drug development approaches and technologies, put forward the “combination of microbial transformation ” research and development concepts and corresponding ways to apply to the development of natural antiviral drugs and pharmacology and toxicology.