论文部分内容阅读
４０只雄兔随机等分为４组：正常对照组（ＮＣ）、高胆固醇血症组（ＨＣ）、氯贝丁酯组（ＣＬ）和Ｌ－精氨酸组（Ｌ－ａｒｇ），实验前及治疗１０周从各组动物耳中央动脉抽血（空腹），酶法检测血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ），ＥＬＩＳＡ法检测脂蛋白（ａ）［Ｌｐ（ａ）］。结果：治疗１０周Ｌ－ａｒｇ组与ＨＣ组ＴＣ无差异（Ｐ＞０．１０），但ＣＬ组ＴＣ明显低于ＨＣ组（Ｐ＜０．０５）。实验１０周ＣＬ组和ＨＣ组的Ｌｐ（ａ）明显高于实验前（Ｐ＜０．０５），虽然实验前后Ｌ－ａｒｇ组的Ｌｐ（ａ）变化不大，但实验１０周时Ｌ－ａｒｇ组和ＨＣ组的Ｌｐ（ａ）有极显著差异，Ｌ－ａｒｇ组低于ＨＣ组（Ｐ＜０．０５）。提示：同ＣＬ组相比，Ｌ－精氨酸虽不降低血清总胆固醇，但对Ｌｐ（ａ）有显著影响。
40 male rabbits were randomly divided into 4 groups: normal control group (NC), hypercholesterolemia group (HC), clofibrate group (CL) and L-arginine group After 10 weeks of treatment, blood samples were taken from the central auricles of the animals (fasting), serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL- a) [Lp (a)]. Results: There was no significant difference (P> 0.10) between L-arg group and HC group at 10 weeks, but TC in CL group was significantly lower than that in HC group (P <0.05). Lp (a) of CL group and HC group at 10 weeks of experiment was significantly higher than that before experiment (P <0.05). Although Lp (a) of L-arg group did not change much before and after the experiment, L-arg The Lp (a) of the HC group was significantly different from that of the HC group (P <0.05). Hint: Compared with CL group, L-arginine did not lower serum total cholesterol, but had a significant effect on Lp (a).